simca-p version 14.1 Search Results


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simca p software  (Umetrics)
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simca p  (Umetrics)
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simca p program  (Umetrics)
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simca software package by umetrics  (Umetrics)
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simcap  (Umetrics)
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simca software  (MKS Instruments)
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opls da model  (Umetrics)
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Umetrics opls da model
Results of metabolomic experiments in the HUA mouse model. (A) Design of mouse serum metabolomic experiments. <t>(B)</t> <t>OPLS-DA</t> of metabolomes between the control and Dp-3G-treated groups. R2Y(cum) and Q2(cum) were 0.990 and 0.452, respectively, indicating global metabolic changes caused by Dp-3G treatment. (C) Z-score plot depicting differential metabolites between the control and Dp-3G-treated groups. (D) Heatmap illustrating differential metabolites between the control and Dp-3G-treated groups. (E-F) Pathway analysis and enrichment analysis of differential metabolites between the control and Dp-3G-treated groups, respectively. (G) Integrated metabolic network analysis of differential metabolites between the control and Dp-3G-treated groups. Metabolites exhibiting decreased levels in the Dp-3G-treated group compared to the control group are depicted in blue, while those showing increased levels are indicated in red. Within the square boxes, bar graphs illustrate the relative level comparison of these metabolites across groups. * indicates significance compared to the control group, with P < 0.05. The data are shown as mean ± SEM (n = 8, 6, and 3 biological replicates for control, AP-treated, and Dp-3G-treated groups, respectively). Metabolite names enclosed in dashed-line boxes signify the reversal of HUA-associated metabolic alterations including folate reported in the literature by Dp-3G, whereas those in solid-line boxes denote reversal including methionine and proline by both interventions.[ , , ] Abbreviations: Dp-3G: delphinidin-3-glucoside, AP: allopurinol. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
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multivariate analyses  (Umetrics)
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Umetrics multivariate analyses
Results of metabolomic experiments in the HUA mouse model. (A) Design of mouse serum metabolomic experiments. <t>(B)</t> <t>OPLS-DA</t> of metabolomes between the control and Dp-3G-treated groups. R2Y(cum) and Q2(cum) were 0.990 and 0.452, respectively, indicating global metabolic changes caused by Dp-3G treatment. (C) Z-score plot depicting differential metabolites between the control and Dp-3G-treated groups. (D) Heatmap illustrating differential metabolites between the control and Dp-3G-treated groups. (E-F) Pathway analysis and enrichment analysis of differential metabolites between the control and Dp-3G-treated groups, respectively. (G) Integrated metabolic network analysis of differential metabolites between the control and Dp-3G-treated groups. Metabolites exhibiting decreased levels in the Dp-3G-treated group compared to the control group are depicted in blue, while those showing increased levels are indicated in red. Within the square boxes, bar graphs illustrate the relative level comparison of these metabolites across groups. * indicates significance compared to the control group, with P < 0.05. The data are shown as mean ± SEM (n = 8, 6, and 3 biological replicates for control, AP-treated, and Dp-3G-treated groups, respectively). Metabolite names enclosed in dashed-line boxes signify the reversal of HUA-associated metabolic alterations including folate reported in the literature by Dp-3G, whereas those in solid-line boxes denote reversal including methionine and proline by both interventions.[ , , ] Abbreviations: Dp-3G: delphinidin-3-glucoside, AP: allopurinol. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
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pls da  (Umetrics)
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Umetrics pls da
Results of metabolomic experiments in the HUA mouse model. (A) Design of mouse serum metabolomic experiments. <t>(B)</t> <t>OPLS-DA</t> of metabolomes between the control and Dp-3G-treated groups. R2Y(cum) and Q2(cum) were 0.990 and 0.452, respectively, indicating global metabolic changes caused by Dp-3G treatment. (C) Z-score plot depicting differential metabolites between the control and Dp-3G-treated groups. (D) Heatmap illustrating differential metabolites between the control and Dp-3G-treated groups. (E-F) Pathway analysis and enrichment analysis of differential metabolites between the control and Dp-3G-treated groups, respectively. (G) Integrated metabolic network analysis of differential metabolites between the control and Dp-3G-treated groups. Metabolites exhibiting decreased levels in the Dp-3G-treated group compared to the control group are depicted in blue, while those showing increased levels are indicated in red. Within the square boxes, bar graphs illustrate the relative level comparison of these metabolites across groups. * indicates significance compared to the control group, with P < 0.05. The data are shown as mean ± SEM (n = 8, 6, and 3 biological replicates for control, AP-treated, and Dp-3G-treated groups, respectively). Metabolite names enclosed in dashed-line boxes signify the reversal of HUA-associated metabolic alterations including folate reported in the literature by Dp-3G, whereas those in solid-line boxes denote reversal including methionine and proline by both interventions.[ , , ] Abbreviations: Dp-3G: delphinidin-3-glucoside, AP: allopurinol. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
Pls Da, supplied by Umetrics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Results of metabolomic experiments in the HUA mouse model. (A) Design of mouse serum metabolomic experiments. (B) OPLS-DA of metabolomes between the control and Dp-3G-treated groups. R2Y(cum) and Q2(cum) were 0.990 and 0.452, respectively, indicating global metabolic changes caused by Dp-3G treatment. (C) Z-score plot depicting differential metabolites between the control and Dp-3G-treated groups. (D) Heatmap illustrating differential metabolites between the control and Dp-3G-treated groups. (E-F) Pathway analysis and enrichment analysis of differential metabolites between the control and Dp-3G-treated groups, respectively. (G) Integrated metabolic network analysis of differential metabolites between the control and Dp-3G-treated groups. Metabolites exhibiting decreased levels in the Dp-3G-treated group compared to the control group are depicted in blue, while those showing increased levels are indicated in red. Within the square boxes, bar graphs illustrate the relative level comparison of these metabolites across groups. * indicates significance compared to the control group, with P < 0.05. The data are shown as mean ± SEM (n = 8, 6, and 3 biological replicates for control, AP-treated, and Dp-3G-treated groups, respectively). Metabolite names enclosed in dashed-line boxes signify the reversal of HUA-associated metabolic alterations including folate reported in the literature by Dp-3G, whereas those in solid-line boxes denote reversal including methionine and proline by both interventions.[ , , ] Abbreviations: Dp-3G: delphinidin-3-glucoside, AP: allopurinol. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Journal: Journal of Advanced Research

Article Title: Urate-lowering effect of delphinidin-3-glucoside in red kidney beans via binding to the FAD site of the XO enzyme

doi: 10.1016/j.jare.2025.04.022

Figure Lengend Snippet: Results of metabolomic experiments in the HUA mouse model. (A) Design of mouse serum metabolomic experiments. (B) OPLS-DA of metabolomes between the control and Dp-3G-treated groups. R2Y(cum) and Q2(cum) were 0.990 and 0.452, respectively, indicating global metabolic changes caused by Dp-3G treatment. (C) Z-score plot depicting differential metabolites between the control and Dp-3G-treated groups. (D) Heatmap illustrating differential metabolites between the control and Dp-3G-treated groups. (E-F) Pathway analysis and enrichment analysis of differential metabolites between the control and Dp-3G-treated groups, respectively. (G) Integrated metabolic network analysis of differential metabolites between the control and Dp-3G-treated groups. Metabolites exhibiting decreased levels in the Dp-3G-treated group compared to the control group are depicted in blue, while those showing increased levels are indicated in red. Within the square boxes, bar graphs illustrate the relative level comparison of these metabolites across groups. * indicates significance compared to the control group, with P < 0.05. The data are shown as mean ± SEM (n = 8, 6, and 3 biological replicates for control, AP-treated, and Dp-3G-treated groups, respectively). Metabolite names enclosed in dashed-line boxes signify the reversal of HUA-associated metabolic alterations including folate reported in the literature by Dp-3G, whereas those in solid-line boxes denote reversal including methionine and proline by both interventions.[ , , ] Abbreviations: Dp-3G: delphinidin-3-glucoside, AP: allopurinol. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Article Snippet: Statistical modeling was performed using the OPLS-DA model in SIMCA-P (Version 14.1, Umetrics).

Techniques: Metabolomic, Control, Comparison